Thymosin β4 improves functional neurological outcome in a rat model of embolic stroke
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چکیده
منابع مشابه
Thymosin beta4 improves functional neurological outcome in a rat model of embolic stroke.
UNLABELLED Thymosin beta4 (Tbeta4) is a developmentally expressed 43-amino acid peptide that inhibits organization of the actin-cytoskeleton by sequestration of G-actin monomers. Tbeta4 improves cardiac function after myocardial infarction in adult mice and promotes healing properties in both dermal and corneal wounds. We tested the hypothesis that Tbeta4 improves functional neurological outcom...
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Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland, U.S.A.; *Center for Combat Casualty and Life Sustainment Research, Department of Pathology, USUHS, Bethesda, Maryland, U.S.A.; †Department of Biochemistry and Molecular Biology, The George Washington University School of Medicine and Health Sciences, Washi...
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BACKGROUND AND PURPOSE Epidemiological studies have demonstrated a high incidence of infections after severe stroke and their prominent role in morbidity and mortality in stroke patients. In a mouse model, it has been shown recently that stroke is coupled with severe and long-lasting immunosuppression, which is responsible for the development of spontaneous systemic infections. Here, we investi...
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ژورنال
عنوان ژورنال: Neuroscience
سال: 2010
ISSN: 0306-4522
DOI: 10.1016/j.neuroscience.2010.05.017